NOTE: Hold off on Apigenin for now because of conflicting statements from this study.
Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.
c-Fos may inhibit chondrogenesis. LSJL strongly upregulates c-Fos.
"To identify the therapeutic potential for cartilage degradation and its action mechanisms, the effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction were examined in the human chondrocyte cell line SW1353. Flavones including apigenin and wogonin strongly inhibited MMP-13 induction in interleukin (IL)-1β-treated SW1353 cells, while flavonols such as kaempferol, quercetin, and flavanone (naringenin) did not at 5 - 25 µM. Apigenin and wogonin primarily inhibit MMP-13 by blocking the c-Fos / activator protein-1 (AP-1) and Janus kinase 2 (JAK2) / signal transducer and activator of transcription 1/2 (STAT1/2) pathways, but not nuclear factor-κB (NF-κB) signaling[this is great as NF-kappaB is needed for chondrogenesis, STAT1 inhibits chondrogenesis, ] . Apigenin was also shown to inhibit extracellular matrix degradation in rabbit cartilage culture. The following study using some synthetic flavones demonstrated that A-ring C-5,7-dihydroxyl and B-ring dihydroxyl substitution at C-2,3, C-2,4, or C-3,4 are important for the suppression of MMP-13 expression. Among these flavones, 2',3',5,7-tetrahydroxyflavone also inhibited both the c-Fos/AP-1 and STAT1/2 pathways. Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways. Furthermore, these findings suggest that some flavonoids have the potential for protecting against collagen matrix breakdown in the cartilage of diseased tissues such as those found in arthritic disorders."
Apigenin seems like an ideal supplement to take with LSJL as it inhibits c-Fos and STAT-1 without inhibiting NF-kappaB. It's present in foods but which ones. Ideally you'd take Apigenin before LSJL so it can inhibit LSJL induced c-Fos expression.
Apigenin will do nothing for growth plates not subjected to mechanical load. Apigenin is present in foods but I'm not sure which foods.
Will Apigenin be effective for those in puberty ?
ReplyDeleteIt's only effective if you're performing LSJL which upregulates c-Fos. If you're in puberty while doing LSJL then it will be effective Apigenin will not be effective if you already get enough in your diet. But there's no way of knowing if you're getting enough.
DeleteRoyal Jelly is the supplement you want if you're in puberty.
Yea i bought royal jelly but unfortunately my mother told my that im allergyc to polen so maybe it will cause allergyc reaction(worsten my asthma),so first i will consult with my doctor first
DeleteOh a quick glance there are about 33 papers on pub med related to royal jelly and allergic reactions maybe there's a way to just take the fatty acid that's beneficial within royal jelly.
Delete