THBS3 is upregulated by LSJL. As well as 2 and 4. And it's a gene involved in height growth, thus it is important to know it's effects to study the effects of LSJL on height growth.
"TSP3 knockout mice show accelerated endochondrial ossification and increased trabecular bone in the femoral head"<-TSP3 may slow down endochondral ossification.
"TSP3, TSP5, and type IX collagen play a role in the chondrocyte organization in the growth plate."<-Perhaps then TSP3 may help form new growth plates?
The upregulating of TSP3 may also indicate the organization of new growth plates by LSJL. TSP3 was highly upregulated by LSJL almost four fold.
According to The interaction of Thrombospondins with extracellular matrix proteins, TSP-3 is expressed in early proliferative and hypertrophic cartilage. TSP-3 binds heparin.
Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head.
According to The interaction of Thrombospondins with extracellular matrix proteins, TSP-3 is expressed in early proliferative and hypertrophic cartilage. TSP-3 binds heparin.
Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head.
"Thrombospondin 3 (TSP3) is structurally similar to cartilage oligomeric matrix protein (COMP/TSP5)"
"the trabecular bone proximal to the femoral head growth plate developed at an earlier time in TSP3-null mice than in wild-type mice. Vascular invasion and ossification start in the femoral heads of TSP3-null mice at 9 weeks, whereas the wild-type femoral head is still composed of hypertrophic chondroctyes in a calcified matrix at 15 weeks."
"Thrombospondin 3 (TSP3; encoded by Thbs3) was first discovered during sequencing of DNA upstream from the start of transcription of the mouse Muc1 (episialin) gene. Subsequent studies showed that these two genes are part of a tightly organized, conserved gene cluster on chromosome 3, E3-F1, which also includes glucocerebrosidase (Gba) and metaxin 1 (mtx1)."
"TSP3 is expressed by both osteoblasts and chondrocytes"
"retinoic acid and vitamin D3 can bind to the axial pore in TSP5." Type 9 collagen interacts with the C-terminus of TSP5.
"[No] phenotypic alterations [were observed] in COMP/TSP5-deficient mice, despite the prevalence of COMP in growth cartilage "
No comments:
Post a Comment