Lateral Synovial Joint Loading Supplement Guide

In an earlier post, I estimated that you can gain 1/4" every two months from lateral synovial joint loading.  This seems to be going along with how St.it(He reported gains of about 0.5 cm for 2 months so about 1/5") and RT(gains of about 1 cm in a month and a half) have reported gaining on the LSJL forum.  Now, what LSJL is good at is good at is inducing chondrogenic differentiation which can cause height growth.  But anything anabolic that can accelerate the rate of cellular proliferation can make this height growth occur faster like HGH.

And incorporating LIPUS and electromagnetic fields(which are important as shown by the pizeoeletric current and the OPG/RANKL gradient).

I'm not going to be going into things like supplement purity and supplement forms(yet).  That's something that will come with time.  Note that all supplements and dosages are at your own risk.  I only study the possible effects of supplements on height increase.  All the information I have on the supplements is based on the studies I present on this blog.  This means that there are possible interactions and side effects that I may overlook.  This list is intended to inspire discussion about the possibility of supplements to increase height and to inspire discussion about possible risks and side effects.  I do not vouch for the safety of any supplements nor do I provide any dosages.  If you want vouches of safety than look to the manufacturer or to an organization such as the FDA.

DNA Protectors like Sam-e may not be necessary with a normal diet but as you do more anabolic activities or take more anabolic supplements your need for these supplements may increase.

I'm will be including supplements like Viagra and Lithium that are only available by prescription.  Because if people are aware of the height increasing potential of certain supplements that might increase the availability.

Dosages of each supplement likely vary based on diet, weight, and activity level.

Basic Lateral Joint Loading Routine(Lateral Loading of the Epiphysis):
-Increases cellular differentiation stem cells to chondrocytes which leads to height growth.
-Increases TGF-Beta, Wnt, and ECM pathways(Hyaluronic Acid).

LIPUS:
-Need more TGF-Beta1.  Won't increase height without TGF Beta.
-Increases Aggrecan Expression.
-Inhibits GSK-3Beta increasing cellular proliferation(which is why it makes bone fractures heal faster).

PEMF:
Increases TGF-Beta release.

Axial Loading(Heavy Weightlifting):
-Increases TGF-Beta
-Increases all kinds of anabolic hormones(net gain in cellular proliferation resulting in more need for anti-oxidants and DNA methylaters)
-Increases need for calories

Endurance Training:
-Can increase VO2 max which can lengthen telomeres
-Increases sensitivity to Growth Hormone.

Now the Supplements:

c-Fos inhibitors:

-Apigenin

Beta-Catenin inhibitors:

-Quercetin

EstrogenReceptorAlpha inhibitors:

-Royal Jelly

ECM(Extracellular Matrix) Protectors:

-As your shear strain increases your need for more ECM increases so endurance training, sprinting or other exercises that cause shear strain on chondrocytes.  You'll notice that your bones will crack more after endurance training(not like a chiropractic crack but more of a dry crack).

So the more you run the more of these you'll need-
-Chondroitin & Glucosamine
-Hyaluronic Acid <-More Important than Chondroitin & Glucosamine for growing taller

Seaweed and Beta-Glycerophosphate:
Beta-Glycerophosphate may play a role in allowing endochondral ossification without periosteum.  Seaweed may help increase ECM levels.

Forskolin:
Increases proteoglycan syntehesis and aggrecan mRNA.

Glucosamine may only have benefits if you engage in a lot of joint taxing exercises whereas hyaluronic acid and chondroitin can help you grow taller during puberty or while performing LSJL.

DNA Protectors:


-B6, B12, Folic Acid(<-The need for these increases the more anabolic activities you engage in or the more anabolic supplements intake)

-Folinic Acid may provide additional protection for DNA.  It should also be noted that Folinic Acid produced an observable increase in growth plate morphology and a non-significant increase in longitudinal bone growth.

-Sam-e(<-You only need this if B6, B12, and Folic Acid are not performing their jobs which they do in most people)

-Telomere Length(Astragalus Membranaceous which also doubles as an anti-oxidant)

-Anakrina and Entarnercept(prescription only substances that act to inhibit TNF-alpha and IL-1Beta, those two compounds are produced endogenously by growth plate chondrocytes and reduce growth)

Increase Cellular Proliferation(May not always increase final adult height but results in faster gains in LSJL and doesn't hurt):


-Examples are HGH, Myostatin Inhibitors, IGF-1, Testosterone.  The higher your cellular proliferation rate the more DNA protectors and anti-oxidants you need.  Use all supplements as directed(Niacin must be taken at a specified large dose).  Remember, that anabolic supplements increase non-bone cells as well such as skin cells, muscle cells, etc.  Usually, adipogenic differentiation is inhibited though.

-Creatine(inhibits Myostatin)

-Lactoferrin(increases chondrocyte proliferation, also available in milk)

The below two supplements are testosterone boosters and have a role in the nitric oxide pathway which can increase height growth:

-Tribulus Terristris

-Horny Goat Weed

-Niacin(enhances the bodies response to HGH when taken in large doses)

-Puerarin(increases cellular proliferation by the PI3K pathway)

-Leptin(increases cellular proliferation)

Lithum:
-Increases cellular proliferation and hypertrophy be inhibiting GSK3Beta however may have negative effects on height like stabilizing Beta-Catenin.  However, inactivation of Beta Catenin & overexpression of Sox9 has been shown to reduce height.  Methylation of Sox9 by CARM1 inhibits Beta-Catenin degradation so upregulating Beta-Catenin may not be needed in some circumstances.

Sophorae Beans:
Increases TGF-Beta and IGF-1 levels.

Cnidium:
Increases bFGF, IGF-1, and BMP-2 levels.

Alfalfa(Ipriflavone):
Increases IGF-1 and Type II Collagen levels.

Growth Plate regulation(Endochondral Ossification Pathways):

Teriparatide:
Parathyroid hormone antagonizes Ihh, Runx2, and TypeX Collagen differentiation plus upregulates CyclinD1.  So basically Parathyroid Hormone delays terminal differentiation and increases chondrocyte proliferation.  PTH also stimulates Nkx3.2 which increases type II collagen(cartilage) and GAG production. Parathyroid Hormone is pro-chondrogenic.

Viagra:
PDE5 inhibitor and stimulates the Nitric Oxide pathway.  The Nitric Oxide Pathway and CNP both increase cGMP levels thus like CNP may increase longitudinal growth.  Viagra is a far more effective NO pathway stimulator than something like arginine, as Viagra targets a NO pathway inhibitor(PDE5) and so may be less susceptible to negative feedback mechanisms than something like Arginine.

Ecdysterone:
Stimulates NO pathway.

Harpogoside:
Inhibits NFKappaB which inhibits height growth in active growth plates.  In bones with no growth plates, NF-kappaB may cause apoptosis of bone cells and stimulate stem cells.  So you shouldn't take Harpogoside if you have active growth plates.

Anti-Oxidants:


Vitamin C:
Vitamin is pro-chondrogeneic.  It is unclear whether levels of Vitamin C above requirements would help increase height however Vitamin C deficiency reduces height. Vitafusion Power C, Gummy Vitamins For Adults, 150-Count.

-Pretty much all anti-oxidants are good except for NAC which inhibits free radicals that are essential for height growth(NADPH).

Melatonin:
Increases levels of TGF-Beta in addition to scavenging free radicals.  Note that Melatonin increases levels of CYP1A2 which metabolizes Melatonin.  Therefore it may be necessary to cycle Melatonin.  Also note, that most doses of Melatonin may be too high and may increase CYP1A2 levels higher than a low dose for the same beneficial effects.  Many studies have found 0.3mg of Melatonin to be effective versus the 3mg in most supplement tablets. Here's 0.5mg Melatonin: Pure Encapsulations Melatonin 0.5 mg - 180 capsules.

-Acai Berry has been shown to be a highly effective anti-oxidant and it is available in foods(Acai berry enhanced smoothies)

Diet:

Silicon Reduced Diet:
-Silicon Deficiency may have possibility to inhibit growth plate closure and increase longitudinal growth.
-Silicon seems to be pro-bone rather than pro-cartilage.  Thus, a silicon deficiency may be favorable to increased chondrogenesis.

So if you want to grow taller faster with LSJL.  First, look at what physically can you do that's anabolic like cardio and weight training.  Then make sure as you increase your activity level increase your levels of chondrocyte protectors as necessary.  Also increase your levels of DNA protectors and anti-oxidants.

With each supplement that's anabolic you try up your anabolic and DNA protector supplement content as well.  For safety, whenever possible go for water soluble supplements like Vitamin C.