How can Acteoside and Harpagoside(also known as Devil's Claw) help with increasing Height?
[Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro].
Just look there's good and bad cholesterol there may be good and bad MMPs. Devil's Claw seems to reduce the production of the good MMPs.
I couldn't get this full study.
I couldn't get this full study.
Harpagoside does reduce COX-2 and COX-2 is bad for height growth(it's bad for height growth by way of MMP-13) To grow taller we want to block MMP-13 expression and enhance MMP-3(LSJL upregulates MMP-3) and MMP-9 expression.
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.
"Preparations of Harpagophytum procumbens [is] known as devil's claw. Pharmacological evaluations have proven tthis herbal drug as an anti-inflammatory and analgesic agent. [We investigate] the mechanism of action of harpagoside, one of the major components of Harpagophytum procumbens, using human HepG2 hepatocarcinoma and RAW 264.7 macrophage cell lines. Harpagoside inhibited lipopolysaccharide-induced mRNA levels and protein expression of cyclooxygenase-2 and inducible nitric oxide in HepG2 cells. These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha. Harpagoside dose-dependently inhibited LPS-stimulated NF-kappaB promoter activity[NF-kappaB can encourage chondrogenic differentiation however] in a gene reporter assay in RAW 264.7 cells, indicating that harpagoside interfered with the activation of gene transcription. Inhibition of the expression of cyclooxygenase-2 and inducible nitric oxide by harpagoside involves suppression of NF-kappaB activation."
But I don't think Harpagoside can help increase height as COX-2 and MMP-13 may actually benefit height increase. Although LPS likely takes inflammatory molecules above equilibrium levels and COX-2 and MMP-13 are likely biphasic with an equilibrium level being most beneficial for height increase.
"Treatment of RAW 264.7 cells with LPS (100 ng/ml) for 24 h significantly increased the release of NO (37 ± 3 μM) by approximately 12-fold compared to that of the untreated cells (3 ± 2 μM)"<-So NO levels were likely well above equilibrium.
"translocation of IκB-α from the cytosol to the nucleus following LPS treatment was blocked by harpagoside."
Acteoside also inhibits MMP-9:
Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-κB-dependent signaling.
Acteoside also inhibited MMP-2.
"MMP-9 can be stimulated by inflammatory cytokines, epidermal growth factor, or phorbol-12-myristate-13-acetate (PMA)"
"calcium (Ca2+) regulates the expression and activation of MMPs, with particular involvement in the control of MMP-12 activity. Increased extracellular Ca2+ levels induce MMP-9 expression in human keratinocytes, inhibiting the influx of Ca2+ and decreasing the mRNA expression of MMP-2. Furthermore, the modulation of intracellular Ca2+ levels can alter the secretion of MMP-1 from migrating keratinocytes"
"TRP vanilloid-type 1 (TRPV1) is one of the several nonselective cationic channels, the activation of which induces Ca2+ influx; however, this influx can be inhibited by a specific antagonist, capsazepine (CPZ). Antagonists of cannabinoid receptors 1 and 2 either alone or in combination with CPZ significantly suppress both cannabidiol-induced tissue inhibitors of metalloproteinase (TIMP)-1 expression and the activation of MAPK p38 and extracellular regulated kinase 1/2 (ERK1/2)"
"TRPV1 can be phosphorylated by PKA, PKC, and Ca2+/calmodulin (CaM)-dependent kinase II (CaMKII)"
Acteoside may increase extracellular Ca2+ thereby inhibiting the influx of Ca2+ into the cell. This is good if the levels of Ca2+ are too high but may inhibit anabolic effects if the Ca2+ are within physiological levels.
So at this time I don't believe either acteoside nor harpagoside has height increase potential as MMP-9 deficiency results in stunted growth.
Of course, if you inhibit Extracellular Matrix degradation in the cartilage you will get taller in your joints. The height will go away if you stop taking it though. In that case, you should just take Hyaluronic Acid which more clearly benefits the ECM.
Of course, if you inhibit Extracellular Matrix degradation in the cartilage you will get taller in your joints. The height will go away if you stop taking it though. In that case, you should just take Hyaluronic Acid which more clearly benefits the ECM.
Herbal products to help increase our heights? This is very interesting. I also believe that it would be safer to take herbal medicines rather than those that have chemical additives.
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