Height Increase Pages

Monday, February 23, 2009

Periosteal Stripping

Stimulation of the Longitudinal Growth of Long Bones by Periosteal Stripping

I couldn't copy and paste from this study.  The periosteum was sripped from one epiphyseal plate to another. In the 15 dogs studied periosteal stipping either did not enhance growth or slightly increased growth by usually 1-3%.


Periosteal stripping did cause bone fractures so that could've been part of the growth cause.

Stimulation of Bone Growth by Periosteal Stripping

Another study where I couldn't copy and paste.  This study was done on children and an increase in length following periosteal stripping was seen. Age range: 6-15 years old.  The mean overgrowth of the periosteal stripped femurs was 0.70cm.


Effects of extensive circumferential periosteal stripping on the microstructure and mechanical properties of the murine femoral cortex.

"Extensive periosteal stripping (PS) is a risk factor for post-radiation pathologic fracture following surgery for extremity soft tissue tumors. The purpose of this study was to determine the effects of PS on bone structure and mechanical properties. Thirty-one skeletally mature mice[12-14 week old female] underwent PS, with circumferential removal of periosteum from an 8-mm segment of the mid-diaphysis of the left femur. Thirty-one control mice underwent sham surgery in which the femur was isolated without manipulation of the periosteum. At 2, 6, 12, or 26 weeks following surgery, the left femora were examined by micro-CT to quantify cortical thickness (CtTh), cross-sectional area (CSA), bone volume (BV), and polar moment of inertia (PMI). Three-point mechanical bend testing was performed and peak load, stiffness, and energy to failure were determined. PS resulted in significantly decreased CtTh, CSA, BV, and PMI at all time points. Peak load, stiffness, and energy to failure were significantly reduced at 2, 6, and 12 weeks. There were no significant differences in mechanical properties at 26 weeks. In this mouse model, extensive circumferential PS resulted in sustained changes in bone structure that were still evident after 6 months, accompanied by reductions in bone strength that persisted for at least 3 months."

"skeletally mature (12-14 week old) female Balb/c mice"<-growth starts to taper off at 12-14 weeks but we can't rule out growth.


Periosteal Stripping versus control.

"Representative 3-dimensional micro-CT reconstructions of femora from mice that underwent periosteal stripping (PS) or sham surgery (sham). Images reflect observations at 12 weeks but similar findings were seen at all four time points."  Periosteal stripping mice are visibly longer although this is just a representation.

A decrease in bone volume could be a mechanism for allowing height growth(bone volume was decreased with periosteal stripping

Surgical technique: Lower limb-length equalization by periosteal stripping and periosteal division.

" The procedure consists of total circumferential stripping followed by transverse division of the periosteum at the proximal, middle, and distal shafts of the femur, tibia, and fibula of the shorter limb.
We retrospectively reviewed 11 children with LLD[limb length discrepency] who underwent PSPD[periosteal stripping or periosteal division]. The average LLD was 6 ± 3.8 cm (range, 3-13 cm). The average age of the patients was 9 ± 2.5 years (range, 7-13 years). Orthoroentgenograms were obtained every 6 to 12 months after the surgery. The minimum followup was 24 months (mean, 52 months; range, 24-108 months).
Limb length equalization (LLE) was achieved in eight of 11 patients in an average of 25 ± 17.2 months (range, 12-60 months) and was maintained throughout the followup. LLE was not achieved in three children whose discrepancy was greater than 10 cm, however, PSPD helped decrease the amount of the discrepancy in all three patients. No major complications were observed in any patients.
PSPD stimulates limb length and LLE is achieved in approximately 2 years after the procedure in the majority of the patients. We believe PSPD should be considered as a surgical option for a LLD up to 6 cm."

"Several hypotheses have been proposed to explain the growth stimulation including hypervascularization or release of the mechanical restraint after the periosteal stripping"

[Influence of stripping periosteum on bone formation in guided tissue regeneration].

"10 mm long segmental defects were created in the diaphyses of both radii in 24 New Zealand rabbits. The defect on the control side was covered with a silicone membrane shaped as a tube. On the experimental side, 10 mm periosteum of both sides of the defect was stripped and the defect was covered with a silicone tube. The animals were killed at the 3rd day and the 1st, 2nd, 3rd, 4th, 6th, 10th, 12th weeks. Samples were treated for radiologic and histologic examinations.
(1) periosteal stripping exerts no effect on callus formation in or out of the tube. (2) osteoblasts in the cambium layer of the periosteum come from bone surface, endosteum or the Haversian envelopes. (3) the tissue in the two layers of the periosteum has different origins, the fibrous layer comes from soft tissue and osteoblasts in the cambium from bone surface or Haversian envelopes.
Stripping periosteum has no influence on bone formation in guided tissue regeneration."
Unfortunately I couldn't get this full study.

Bone growth and modeling changes induced by periosteal stripping in the rat.

 "In this study, the changes in longitudinal bone growth and metaphyseal modeling induced by mid diaphyseal periosteal stripping in the rat femur were analyzed by means of histomorphometrical techniques. One hundred forty-four male 30-day-old Sprague-Dawley albino rats distributed in 4 groups of 36 were studied: a control group, a sham group, a group with middiaphyseal right femoral periosteal stripping, and a group with a polyethylene ring wrapped around the stripped zone. The animals were euthanized at 1, 2, or 4 weeks from the start of the experiment, after double tetracycline labeling. A statistically significant, albeit small, longitudinal overgrowth of stripped femurs was observed after a latency period of 2 to 4 weeks. The metaphyseal diameters were greater in stripped femurs than nonstripped femurs. This finding was associated with a lower osteoclastic index in the external metaphyseal surface and with a lower bone formation rate in the internal surface of the metaphyseal cortex."

Couldn't get this study either.  So stripping periosteum reduces bone resorption on the external metaphsyeal surface and reduces bone formation on the internal metaphyseal surface.  So more bone is being formed on the external metaphyseal surface. Would this increase height?

Periosteal stripping in achondroplastic children. Little effect on limb length in 10 cases.
[couldn't get full study]

"We present a prospective study of the results of periosteal stripping and division in 10 achondroplastic children. A single limb (femur and tibia) was operated on and the change in actual length of each bone and the percentage change in growth compared to that of the non-operated limb was measured by scanogram. The mean absolute increase in growth was small, measuring 3 mm for the femur and 2 mm for the tibia. There was no measurable growth difference after 18 months. This method of increasing limb length in achondroplastic children prior to definitive and extensive lengthening procedures is not recommended."

Usually achondroplastic children have elevated levels of FGFR3 decreasing height so maybe periosteal stripping doesn't work if FGFR3 levels are too high or the periosteum is a limiting factor.  If the periosteum is limiting your growth removing it will increase height.  If something else is limiting the growth then periosteal stripping won't affect height.


"Periosteal stripping and periosteal division (PSPD) promotes growth of the long bone of children with leg length discrepancy (LLD). We performed PSPD when LLD was observed at the time of implant removal surgery after proximal femoral osteotomy for Perthes disease. This study aimed to clarify the efficacy and safety of PSPD for acquired LLD related to Perthes disease.

 Methods: This retrospective study enrolled 10 patients treated with PSPD and 6 control patients who declined the PSPD for LLD associated with Perthes disease. The lengths of the femur, tibia and entire leg were measured in the full-length standing radiographs at baseline and final follow-up. Baseline was defined as the time of the last preoperative observation. LLD and changes in LLD (ΔLLD) were measured. The correlation of ΔLLD with age at time of surgery, follow-up period, and extent of PSPD was investigated. 

Results: Patients’ mean age and LLD at baseline were 9.4 years and 20.5 ± 4.6 mm in the PSPD group and 10.2 years and 11.5 ± 10.0 mm in the control group. With a mean follow-up period of 4.3 years, the PSPD group showed a mean ΔLLD decrease of 13.9 mm, which was significantly greater than that of the control group at 3.2 mm with a mean follow-up period of 5.4 years. Logistic regression analysis revealed that age at the time of surgery was a significant factor for obtaining >10 mm ΔLLD with PSPD and the cutoff value by the receiver operating characteristic curve was 9.6 years (sensitivity, 0.83; specificity 0.83). Conclusion: PSPD seemed to be a safe and effective surgical option for LLD associated with Perthes disease. The age at the time of surgery negatively correlated with the amount of LLD correction. Obtaining >10 mm LLD correction is more likely if the patients are <10 years of age."



". In the control group, the affected side also tended to show greater changes than the healthy side, but only the tibia length showed a significant difference in the amount of change"<-looking at the control group there seems to be mixed results with periosteal stripping but if you look at the table below you see that it does seem to increase leg length.

"The cause of overgrowth of the long bone due to PSPD include changes in the hemodynamics and the external force applied to the growth plate. periosteal stripping [causes] a blockage of blood flow to the cortical bone and increased blood flow to the growth plate"

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